Single cell gene expression profiling of CARD9 WT and R101C murine skin infected with Trichophyton rubrum
Summary:
We used scRNA-seq to understand how CARD9 R101C remodels skin immunity and cell state in response to fungal infection in a mouse model of dermatophytosis.
Overall Design:
We performed single cell RNA sequencing (scRNAseq) of skin from WT and CARD9 R101C mice infected with T. rubrum at day two (D2) and day nine (D9) post-infection (3 replicates of each WT and CARD9 R101C at each timepoint)
Cell Clustering
DEG Results
Gene
logFC
p-value
Score
Group
CellPhoneDB Analysis
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